Combined efforts of developmental biologists and cancer geneticists have outlined the canonical Wnt/Wingless (Wg) signalling pathway ... catenin in colon-cancer cells. Figure 1: Map of the APC ...

Nat Clin Pract Gastroenterol Hepatol. 2006;3(5):267-274. The WNT signaling pathway. (A) In the absence of WNT binding to frizzled, dishevelled remains unactivated and β-catenin is targeted for ...