Deep inside the brains of those with the condition, dopamine-producing neurons take a major hit as insoluable clumps of a protein called alpha-synuclein accumulate, gradually depriving patients of ...

Researchers have discovered how a cell surface protein called Aplp1 can play a role in spreading material responsible for Parkinson's disease from cell-to-cell in the brain.

However, importantly, the results of our genetic screen have given us a way to ask important questions about these other aspects of alpha-synuclein toxicity,” she said. Lindquist also said the ...

Dopamine plays a role in controlling movement, cognition, learning, and mood, explaining the dementia and difficulty with motor control exhibited by patients with deficits in the production of this ...

“I don’t want you to think of the cells as a pump of dopamine,” he says ... established – a toxic form of a protein called alpha-synuclein that accumulates inside neurons in clusters ...

He injected them with the reactive alpha-synuclein fragment and monitored their weight and ... “All of the enteric neurons, to my knowledge, express ANNA1 in the nucleus, but only the dopamine neurons ...

Parkinson’s disease is a brain disorder that affects movement, making everyday tasks difficult for nearly one million people ...

Manganese has been previously shown to bind with the protein alpha-synuclein, causing it to misfold ... damages these cells. The loss of dopamine-producing cells is a hallmark of Parkinson's ...